Improving protein succinylation sites
WebSuccinylation, which is among the more recently discovered PTMs, is comparatively unique 3. Like methyla-tion, acetylation or ubiquitination, succinylation also occurs on lysine … WebApr 8, 2024 · LDHA succinylation and protein levels were analysed by immunoblotting using the indicated antibodies. C K1 cells were transfected with HA-LDHA and pCDNA-GLTC (or the empty vector control) for 48 h ...
Improving protein succinylation sites
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WebNov 11, 2024 · Succinylation is an important posttranslational modification of proteins, which plays a key role in protein conformation regulation and cellular function control. Many studies have shown that succinylation modification on protein lysine residue is closely related to the occurrence of many diseases. To understand the mechanism of … WebOct 8, 2024 · Improving protein succinylation sites prediction using embeddings from protein language model Introduction. Post-translational modifications (PTMs) are important regulators of proteins that modulate a myriad of... Dataset and methods. We used the …
WebJun 27, 2013 · After removing overlapping sites, we identified a total of 2,565 Lys succinylation sites from 779 proteins in mouse cells ( Figures 1 B and 1C). We found that some proteins were highly succinylated, including CPS1 with 47 sites and hydroxyacyl-coenzyme A dehydrogenase (HADHA) with 32 sites ( Figure 1 C and Tables S1 A–S1B). WebJun 17, 2024 · Quantitative analysis showed that the intensities of nine succinylation sites on eight proteins were significantly altered ( p < 0.05) in turnip shoots after 8 h of Cd stress. These differentially succinylated sites were highly conserved in Brassicaceae species and mostly located in the conserved domains of the proteins.
WebMar 31, 2024 · Barley (Hordeum vulgare L.)—a major cereal crop—has low Pi demand, which is a distinct advantage for studying the tolerance mechanisms of phosphorus deficiency. We surveyed dynamic protein succinylation events in barley roots in response to and recovery from Pi starvation by firstly evaluating the impact of Pi starvation in a Pi-tolerant (GN121) … WebAug 18, 2024 · Abstract. Protein succinylation is an important post-translational modification (PTM) responsible for many vital metabolic activities in cells, including …
WebProtein succinylation is a type of post-translational modification (PTM) that occurs on lysine sites and plays a key role in protein conformation regulation and cellular function control.
WebEnter the email address you signed up with and we'll email you a reset link. dan brown the lost symbol audiobookWebThe succinylation modification of protein participates in the regulation of a variety of cellular processes. Identification of modified substrates with precise sites is the basis for … dan brown teaches writing thrillersWebThe potential role of succinylation is under investigation, but as addition of succinyl group changes lysine's charge from +1 to −1 (at physiological pH) and introduces a relatively large structural moiety (100 Da), bigger than acetylation (42 Da) or methylation (14 Da), it is expected to lead to more significant changes in protein structure and … birds of a feather full quoteWebSuccinylation Links Metabolism to Protein Functions. Post-translational modifications (PTMs) are important regulators of protein function, and integrate metabolism with … dan brown strateny symbolWebImproving protein succinylation sites prediction using embeddings from protein language model Protein succinylation is an important post-translational modification (PTM) responsible for many vital metabolic activities in cells, including cellular respiration, regulation, and repair. birds of a feather hogwarts mysteryWebOct 8, 2024 · A novel approach that combines features from supervised word embedding with embedding from a protein language model called ProtT5-XL-UniRef50 in a deep learning framework to predict protein succinylation sites is presented. Protein succinylation is an important post-translational modification (PTM) responsible for many vital … birds of a feather full idiomWebDownload scientific diagram Two Sample Logos of the succinylation lysine sites compared to unlabeled sites. Different color of symbles represents different physical and chemical properties ... dan brown the lost symbol dvd